Druginduced parkinsonism dip is the secondmostcommon etiology of parkinsonism in the elderly after parkinson s disease pd. Parkinsonism causes, atypical parkinsonism everyday health. Many patients with dip may be misdiagnosed with parkinson s disease pd because the clinical feature of. Druginduced parkinsonism dip is condition that mimics parkinsons disease. Pdf on sep 1, 2016, pierre blanchet and others published druginduced parkinsonism. Druginduced parkinsonism must always be suspected when parkinsonian symptom like rigidity, tremor, or postural instability appear in patients receiving drug. Drug induced parkinsonism dip is the most common etiology in all aged group of people. Any patient presenting to outpatient department with symptoms suggestive of parkinsonism syndrome should undergo detailed history about medication taken during past year. Druginduced parkinsonism parkinsons disease research. Many patients with dip may be misdiagnosed with pd because the clinical features of these two conditions are indistinguishable. In 1817, james parkinson described the shaking palsy now known as parkinson disease pd. Descriptions evolved until the term parkinsonism now refers to a syndrome characterized by the presence of tremor, rigidity, and bradykinesia in addition to loss of postural reflexes and freezing. Druginduced parkinsonism dip has been known for 60 years.
It is usually the side effect of drugs that affect dopamine levels in the brain, such as antipsychotics, some calcium channel blockers and stimulants like amphetamines and cocaine. Other risk factors include a family history of parkinson s and affective disorders. Idiopathic parkinson s disease ipd vs drug induced parkinsonism over the time biggest challenge encountered in dip is to differentiate it from ipd. Drug induced parkinsonism is more prevalent in older people and is twice as common in women than men. Druginduced parkinsonism journal of clinical neurology. Any drug that which leads to blockage of the action of dopamine or reduces the store of dopamine can cause parkinsonism.
There may be a genetic predisposition to drug induced parkinsonism. Druginduced parkinsonism dip is the secondmostcommon etiology of parkinsonism in the elderly after parkinsons disease pd. Druginduced parkinsonism is more prevalent in older people and is twice as common in women than men. Druginduced parkinsonism dip is the second most common cause of parkinsonism after parkinsons disease. However, in any parkinsonian patient, one must obtain a. Druginduced parkinsonism article pdf available in journal of clinical neurology 81. Recovering from drug induced parkinsons disease youtube. Drug induced parkinsonism can be difficult to distinguish from parkinson s, though the tremors and postural instability may be less severe.
Pharmacists letter includes 12 issues every year, with brief articles about new meds and hot topics. The incidence of drug induced parkinsonism increases with age. Characterized mainly by rigidity and bradykinesia, it has less prominent trem or. A small number of people develop parkinsonism after taking certain medications. There may be a genetic predisposition to druginduced parkinsonism. One or more of the cardinal features of tremor, rigidity or bradykinesia. Druginduced parkinsonism this condition may be caused by a number of different drugs, and it sometimes disappears when a person stops taking the drug or medication. It is the second leading cause of parkinsonism, but still. Differentiating druginduced parkinsonism from parkinsons disease. Druginduced parkinsonism is the second most common cause.